Well this was a surprise! The Steve Carell 3D animated film Despicable Me opened up to $60.1 million its first weekend in theaters. This was the best opening for Universal since Fast & Furious was released a year and a half ago. The Twilight Saga: Eclipse dropped to the #2 slot with $33.4 million in its second weekend, bringing its US total to over $237 million. The Predators reboot came in third with a very solid $25.3 million. With a budget of just $40 million, this Fox Sci-Fi film will make a very tidy profit.

See the full US Top 10 after the jump.

US Top 10 Box Office Friday July 9 – Sunday July 11 2010

1	N	Despicable Me	Uni.	$60,117,000	–	3,476	–	$17,295	$60,117,000	$69	1
2	1	The Twilight Saga: Eclipse	Sum.	$33,400,000	-48.5%	4,468	–	$7,475	$237,000,000	$68	2
3	N	Predators	Fox	$25,300,000	–	2,669	–	$9,479	$25,300,000	$40	1
4	3	Toy Story 3	BV	$22,000,000	-27.3%	3,753	-275	$5,862	$340,200,000	$200	4
5	2	The Last Airbender	Par.	$17,150,000	-57.5%	3,203	+34	$5,354	$100,227,000	$150	2
6	4	Grown Ups	Sony	$16,400,000	-13.9%	3,463	-71	$4,736	$111,315,000	$80	3
7	5	Knight & Day	Fox	$7,850,000	-24.8%	2,628	-476	$2,987	$61,939,000	$117	3
8	6	The Karate Kid	Sony	$5,700,000	-28.8%	2,458	-651	$2,319	$164,600,000	$40	5
9	7	The A-Team	Fox	$1,800,000	-43.6%	1,236	-917	$1,456	$73,971,000	$110	5
10	11	Cyrus	FoxS	$1,375,000	+77.5%	200	+123	$6,875	$3,521,000	$7	4